Hydrochloric Acid → HCID 23516936, compound

Participants

Reaction Steps

(S)-5,6-Dimethylspiro[7-azaindoline-3,3′-(1,2,3,6-tetrahydropyridin)]-2-one dihydrochloride. The compound from STEP E, second peak (190 mg), was deprotected using 0.5 M HCl in methanol-ether at room temperature for 15 h. Evaporation of solvents gave the title compound in quantitative yield. It is tentatively assigned the S configuration based on its elution pattern on the chiral column. MS (TSP+) m/z [M+H]+: 230. 1H-NMR (d4-MeOH): 7.80 (s, 1H), 6.11 (d, 1H), 5.54 (d, 1H), 3.75 (m, 2H), 3.52 (dd, 2H), 2.4 (s, 3H), 218 (s, 2H).

Provenance & Evidence