2-Acetylpyridine → HCID 69677199, compound

Participants

Reaction Conditions

Reaction Steps

To a well stirred solution of NaOH (12 g, 0.3 mmole) in H2O (125 ml) and methanol (250 ml) at 0° C. was added 3,5-dimethoxy benzaldehyde (19 g, 0.11 mmole) followed by a solution of 2-acetylpyridine (14.4 g, 0.12 mmole) in MeOH. The reaction was stirred at 0° C. for 1 hour and at room temperature for 16 hours. The precipitate was filtered and recrystallized from MeOH (Yield: 18 mg, 57%). The preparation scheme is shown below:

Provenance & Evidence