Cesium carbonate → HCID 23500250, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 14 g of 1-butoxycarbonyl-1,4,7-tri-(p-toluenesulfonyl)-1,4,7-triazaheptane, 7.04 g of 9-bromo-1-nonanol, and 34.25 g of Cs2CO3 in 700 ml of DMF was stirred at 65° C. for 24 hours. The mixture was cooled and concentrated under reduced pressure. CH2Cl2 was added and the remaining solid was filtered and discarded. The solvent was evaporated to give 22.17 g of crude product which was purified on silica gel and eluted with CH2Cl2/ethyl acetate (50/1-20/1 v/v). 7.95 g of pure product was obtained. The preparation scheme is shown below:

Provenance & Evidence