Methanol → HCID 23500293, compound

Participants

Reaction Steps

A mixture of diethylene triamine (460 ml, 4.3 mole) and (2-iodoethoxy) ethoxyethanol (7.30 g, 28 mmole) was stirred-at room temperature for 1 hour. The excess of diethylenetriamine was removed by distillation under vacuum. The residue was then treated with aqueous Satd NaOH, extracted with CH2Cl2, dried over MgSO4/Na2CO3, filtered, and concentrated to give a yellow oil. This was purificated by column chromatography on silica with CH3OH/NH40H (10:1), then (5:1) to give 1.43 g (33%) of the title compound as a pale yellow oil. The reaction is shown schematically as follows:

Provenance & Evidence