Ethanol hydrochloride → HCID 10308395, compound

Participants

Reaction Steps

A solution of carboxylic acid 24 (3.5 g, 13 mmol) in HCl/EtOH(100 ml) was refluxed for 2 hr. The reaction was then cooled, concentrated and the product was dissolved in EtOAc, washed with sat NaHCO3, dried over MgSO4, and concentrated to give a solid. The solid was triturated with CH2Cl2, filtered to give the desired product (3.5 g, 92%); Mp=221-223° C.; 1NMR (DMSO-d6) δ 9.90 (s, 1 H), 9.55(s, 1 H), 7.73 (d, 2 H, J=8.5 Hz), 7.23 (d, 1 H, J=2.1 Hz), 7.17 (d. 1 H, J=2.5 Hz), 7.12 (s,1 H), 6.88 (d, 2 H, J=8.5 Hz), 4.43-4.35 (m, 2 H), 1.41 (t, 3 H, J=7.0 Hz); MS 297 (M−H)−.

Provenance & Evidence