HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 10285960, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Ethynyl-4-methoxybenzene | HCID 251020 | — |
| Reactant | 4-Fluoro-2-iodophenol | HCID 10171417 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | DMF Diethylamine | HCID 86589549 | — |
| Product | HCID 10285960 | HCID 10285960 | — |
Reaction Steps
A solution of 4-Fluoro-2-Iodophenol [2713-29-3] (0.9 g, 3.8 mmol), 4-Methoxyphenylacetylene (0.53 g, 4.0 mmol), PdCl2P(PH3)2 (70 mg), and CuI (50 mg) in DMF/Diethylamine (10 ml) was heated to 60° C. After 1 hr, the reaction was cooled and poured into water which was extracted with EtOAc. The organic layer was dried over MgSO4, filtered and concentrated to give a solid which was triturated with MeOH, and filtered to give 83 as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06774248B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-86bc394c8bed4da79fbb1eb646f523e5 |
| Source note | uspto-grants-2004_08 |