5-tert-Butyl-2-(4-methoxy-phenyl)-benzofuran → 4-(5-tert-Butyl-benzofuran-2-yl)-phenol

Participants

Reaction Conditions

Reaction Steps

Compound 84 was treated with Pyridine HCl (5 g) and heated to 200° C. After 1 hr, the reaction was cooled and diluted with water. The aqueous layer was extracted with EtOAc, dried over MgSO4, filtered and the crude product was purified by column chromatography (eluant 25% EtOAc/hexanes) to give a solid (0.18 g, 17%); Mp=172-174° C.; 1H NMR (DMSO-d6) δ 9.83 (s, 1H), 7.70 (d, 2 H, J=8.9 Hz), 7.56 (d, 1 H, J=1.7 Hz), 7.45 (d, 1 H, J=9.0 Hz), 7.32 (dd, 1 H, J=9.0 Hz, 2.1 Hz), 7.11 (s, 1 H), 6.87 (d, 2H, J=8.5 Hz); MS 265 [M−H]−

Provenance & Evidence