Pyridinium chloride → HCID 10149371, compound

HRID 1836025Notes

Reaction equation

HRID 1836025 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:12]=3[CH:13]=2)=[CH:5][CH:4]=1.Cl.N1C=CC=CC=1>O>[F:21][C:18]([F:19])([F:20])[C:15]1[CH:16]=[CH:17][C:11]2[O:10][C:9]([C:6]3[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=3)=[CH:13][C:12]=2[CH:14]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 22221599HCID 22221599, compound

Product 1

HCID 10149371HCID 10149371, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
200 °C

Procedure

Compound 88 was treated with Pyridine HCl (5 g) and heated to 200° C. After 1 hr, the reaction was cooled and diluted with water. The aqueous layer was extracted with EtOAc, dried over MgSO4, and the product was purified by column chromatography (eluant 25% EtOAc/hexanes) to give the product as a solid: (0.025 g, 4.8%); MS 277 [M−H]−

Workup

  1. temperaturethe reaction was cooled
  2. extractionThe aqueous layer was extracted with EtOAc
  3. dry with materialdried over MgSO4
  4. customthe product was purified by column chromatography (eluant 25% EtOAc/hexanes)

Sources & evidence

ORD record
ord-40f12f1e4b154452bb7ba0d38dbcfa93
Source dataset
uspto-grants-2004_08
Patent number
US06774248B2

Reaction notes

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