Dimethyl Sulfoxide → 1-(4-Amino-quinazolin-7-ylmethyl)-4-prop-2-ynyl-piperazin-2-one
Reaction equation
[CH2:1]([C:2]#[CH:3])[Br:4].[CH3:30][S:31]([CH3:32])=[O:33].[K+:24].[K+:25].[NH2:5][c:6]1[n:7][cH:8][n:9][c:10]2[cH:11][c:12]([CH2:16][N:17]3[C:18](=[O:23])[CH2:19][NH:20][CH2:21][CH2:22]3)[cH:13][cH:14][c:15]12.[O-:26][C:27]([O-:28])=[O:29]>>[CH:1]#[C:2][CH2:3][N:20]1[CH2:19][C:18](=[O:23])[N:17]([CH2:16][c:12]2[cH:11][c:10]3[n:9][cH:8][n:7][c:6]([NH2:5])[c:15]3[cH:14][cH:13]2)[CH2:22][CH2:21]1Participants
6
Sources & evidence
- ORD record
- ord-100c286029914c5cb410af07da5eb414
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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