Hydrochloric Acid → HCID 22221603, compound

Participants

Reaction Steps

To a solution of 2 (1.2 g, 4.3 mmol) and Trimethylsilyltrifluoromethane (20 ml of 0.5M in THF, 10 mmol) in THF (20 ml) was added TBAF (10 ml of 1.0M in THF, 10 mmol) and the reaction was stirred at rt. After 30 min, the rextion was poured into 2N HCl and extracted with ether. The ether was dried, concentrated and the product was purified by column chromatography (eluent 10% EtOAc/Hex) to give 139 as a solid (1.2 g, 80%); Mp=120-122° C.; 1H NMR(CDCl3) δ 7.75 (d, 2 H, J=8.8 Hz), 7.15-6.95 (m, 4 H), 6.84 (s, 1 H), 5.59 (m, 1 H), 3.86 (s, 6 H); MS 353 (M+H)+

Provenance & Evidence