Ammonia → HCID 23498800, compound

HRID 1836112Notes

Reaction equation

HRID 1836112 reaction equation
[CH:1]1([C:6]2[C:10]([N+:11]([O-:13])=[O:12])=[C:9]([C:14]([O:16]CC)=O)[O:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH3:19]>>[CH:1]1([C:6]2[C:10]([N+:11]([O-:13])=[O:12])=[C:9]([C:14]([NH2:19])=[O:16])[O:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 23498805HCID 23498805, compound

Product 1

HCID 23498800HCID 23498800, compoundYield 62%

Procedure

51.59 g (203 mmol) of ethyl 3-cyclopentyl-4-nitro-isoxazole-5-carboxylate (example IV) are stirred, at room temperature for 3 hours, in 600 ml of a 2M solution of ammonia. The solvent is removed in vacuo and the residue is triturated with cyclohexane and dried in vacuo. 31.17 g (62%) of colorless solid are obtained.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe residue is triturated with cyclohexane
  3. customdried in vacuo

Sources & evidence

ORD record
ord-59b300ca7c1a470f8ca089144f407c0e
Source dataset
uspto-grants-2004_08
Patent number
US06777416B2

Reaction notes

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