Methanol → HCID 136397837, compound

Participants

Reaction Steps

2.56 g (7.45 mmol) of 3-cyclopentyl-4-{[2-(4-methoxyphenyl)acetyl]amino}-isoxazole-5-carboxamide (example X) are heated under reflux for 16 hours, together with 4.3 g of potassium hydroxide, in 170 ml of methanol. The solvent is removed in vacuo and the residue is taken up in dichloromethane; the solution is washed with 1N hydrochloric acid and water, after which the organic phase is dried over sodium sulfate and the solvent is removed. The residue is purified by chromatography (cyclohexane/ethyl acetate=2:1).

Provenance & Evidence