Chlorosulfonic acid → HCID 135678136, compound

HRID 1836117Notes

Reaction equation

HRID 1836117 reaction equation
[CH:1]1([C:6]2[C:10]3[N:11]=[C:12]([CH2:16][C:17]4[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=4)[NH:13][C:14](=[O:15])[C:9]=3[O:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:25]S(O)(=O)=O>>[Cl-:25].[CH:1]1([C:6]2[C:10]3[N:11]=[C:12]([CH2:16][C:17]4[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=4)[NH:13][C:14](=[O:15])[C:9]=3[O:8][N:7]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 135678137HCID 135678137, compound

Product 1

HCID 135678136HCID 135678136, compound

Procedure

1.23 g (3.78 mmol) of 3-cyclopentyl-5-(4-methoxybenzyl)-isoxazolo[4,5-d]-pyrimidin-7(6H)-one (example XI) are introduced in portions into 2.51 ml of chlorosulfonic acid at 0° C. The reaction mixture is stirred at room temperature for 16 hours. It is poured onto ice water and the precipitate is filtered off with suction and dried in vacuo.

Workup

  1. additionIt is poured onto ice water
  2. filtrationthe precipitate is filtered off with suction
  3. customdried in vacuo

Sources & evidence

ORD record
ord-a27175d7ecca4cad948a46f658ace19a
Source dataset
uspto-grants-2004_08
Patent number
US06777416B2

Reaction notes

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