3-[3-(4-Methylpiperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde → HCID 10413508, compound

HRID 1836131Notes

Reaction equation

HRID 1836131 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][C:11]2[C:19]3[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=3[NH:13][C:12]=2[CH:20]=O)[CH2:4][CH2:3]1.[CH2:22]([S:24]([C:27]1[CH:28]=[C:29]2[C:33](=[CH:34][CH:35]=1)[NH:32][C:31](=[O:36])[CH2:30]2)(=[O:26])=[O:25])[CH3:23]>>[CH2:22]([S:24]([C:27]1[CH:28]=[C:29]2[C:33](=[CH:34][CH:35]=1)[NH:32][C:31](=[O:36])/[C:30]/2=[CH:20]\[C:12]1[NH:13][C:14]2[CH2:15][CH2:16][CH2:17][CH2:18][C:19]=2[C:11]=1[CH2:10][CH2:9][CH2:8][N:5]1[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]1)(=[O:25])=[O:26])[CH3:23]

Participants

3

Reactant 2

HCID 225711323-[3-(4-Methylpiperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehydeHCID 23498854HCID 23498854, compound

Product 1

HCID 10413508HCID 10413508, compound

Procedure

3-[3-(4-Methylpiperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde, prepared as described in Example 2, was condensed with 5-ethylsulfonyloxindole (Example 5) following the procedure described in Example 1 above. The reaction mixture was purified by flash chromatography and eluting with (dichloromethane: methanol 30/1, 20/1, 15/1) to give the desired product.

Workup

  1. customThe reaction mixture was purified by flash chromatography
  2. washeluting with (dichloromethane: methanol 30/1, 20/1, 15/1)

Sources & evidence

ORD record
ord-4fea9d4f2299475a8ee644682d23fff0
Source dataset
uspto-grants-2004_08
Patent number
US06777417B2

Reaction notes

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