反应详情

4-[3-(4-Oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionyl]-piperazine-1-carboxylic acid tert-butyl ester (37.5mg, 0.1 mmol) was added to 3 ml of dichloromethane at 0° C. followed by the addition of 1 ml of 20% trifluoroacetic acid. The reaction mixture was stirred at room temperature for 8 hours. The reaction solution was rotary evaporated and diluted with 1,4-dioxane. The reaction solution was concentrated at 30° C. till dryness then purified by flash chromatography and eluting with (chloroform: methanol: ammonia 20/1/0.1, 15/1/0.1) to provide 3-(3-oxo-3-piperazin-1-yl-propyl)-1,5,6,7-tetrahydro-indol-4-one.

1. customThe reaction solution was rotary evaporated
2. additiondiluted with 1,4-dioxane
3. concentrationThe reaction solution was concentrated at 30° C. till dryness
4. customthen purified by flash chromatography
5. washeluting with (chloroform: methanol: ammonia 20/1/0.1, 15/1/0.1)