HCID 23498854, compound → HCID 23518512, compound

HRID 1836137Notes

Reaction equation

HRID 1836137 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]2[C:23]3[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=3[NH:17][C:16]=2[CH:24]=O)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH2:26]([S:28]([C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][CH:39]=1)[NH:36][C:35](=[O:40])[CH2:34]2)(=[O:30])=[O:29])[CH3:27]>>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][N:9]([CH2:12][CH2:13][CH2:14][C:15]2[C:23]3[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=3[NH:17][C:16]=2/[CH:24]=[C:34]2\[C:35](=[O:40])[NH:36][C:37]3[C:33]\2=[CH:32][C:31]([S:28]([CH2:26][CH3:27])(=[O:30])=[O:29])=[CH:39][CH:38]=3)[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 23498854HCID 23498854, compoundHCID 86588562HCID 86588562, compound

Product 1

HCID 23518512HCID 23518512, compound

Procedure

4-[3-(2-Formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propyl]-piperazine-1-carboxylic acid ethyl ester (65 mg, 0.1 87 mmol), prepared as described in Example 8, was condensed with 5-ethylsulfonyloxindole (61 mg, 1.01 eq.) give the desired product.

Sources & evidence

ORD record
ord-4b85037a002c46cc849f402fb7ae863e
Source dataset
uspto-grants-2004_08
Patent number
US06777417B2

Reaction notes

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