Acetic Anhydride → HCID 23498840, compound

HRID 1836138Notes

Reaction equation

C([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]2[C:23]3[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=3[NH:17][C:16]=2[CH:24]=[O:25])[CH2:8][CH2:7]1)=O)C.Cl[C:27](OCC)=O.C(OC(=O)C)(=O)C>>[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]2[C:23]3[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=3[NH:17][C:16]=2[CH:24]=[O:25])[CH2:8][CH2:7]1)(=[O:3])[CH3:27]

Participants

Reactant 3

HCID 7918Acetic Anhydride

HCID 10928Ethyl chloroformate

HCID 86588562HCID 86588562, compound

Product 1

HCID 23498840HCID 23498840, compound

Procedure

3-[3-(4-Acetyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde was prepared as described for 4-[3-(2-Formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propyl]-piperazine-1-carboxylic acid ethyl ester in Example 8 but substituting ethyl chloroformate with with acetic anhydride.

Sources & evidence

ORD record: ord-4243b1e6b6354b86ac60239c743257d8
Source dataset: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06777417B2

Reaction notes

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