HRID1836148

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10176909

未命名化合物

结构：CCOC(=O)CN1CCN(CCCc2c(C=O)[nH]c3c2CCCC3)CC1

HCID86588564

未命名化合物

PRODUCTS

生成物

$结构：CCOC(=O)CN1CCN(CCCc2c(/C=C3\C(=O)Nc4ccc(S(=O)(=O)NC)cc43)[nH]c3c2CCCC3)CC1$

HCID23518511

未命名化合物

PROCEDURE

实验过程

{(4-[3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propyl]-piperazin-1-yl}-acetic acid ethyl ester (60 mg, 0.1 73 mmol) was condensed with 5-methylaminosulfonyloxindole (45 mg, 0.1 9 mmol, 1.1 eq.) following the procedure used in Example 1 above. The reaction mixture was purified by flash chromatography (dichloromethane/methanol 10/1) to give the desired product.

WORKUP

后处理

customThe reaction mixture was purified by flash chromatography (dichloromethane/methanol 10/1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-25edbaacec5e4b9fb53560d262e84c40
来源数据集: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06777417B2
来源说明: uspto-grants-2004_08

反应 SMILES

[CH2:1]([O:3][C:4](=[O:26])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]2[C:23]3[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=3[NH:17][C:16]=2[CH:24]=O)[CH2:8][CH2:7]1)[CH3:2].[CH3:27][NH:28][S:29]([C:32]1[CH:33]=[C:34]2[C:38](=[CH:39][CH:40]=1)[NH:37][C:36](=[O:41])[CH2:35]2)(=[O:31])=[O:30]>>[CH2:1]([O:3][C:4](=[O:26])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]2[C:23]3[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=3[NH:17][C:16]=2/[CH:24]=[C:35]2\[C:36](=[O:41])[NH:37][C:38]3[C:34]\2=[CH:33][C:32]([S:29](=[O:31])(=[O:30])[NH:28][CH3:27])=[CH:40][CH:39]=3)[CH2:8][CH2:7]1)[CH3:2]