N-methyl-2-oxoindoline-5-sulfonamide → HCID 23518503, compound

HRID 1836157Notes

Reaction equation

HRID 1836157 reaction equation
[CH3:1][CH:2]1[NH:7][CH:6]([CH3:8])[CH2:5][N:4]([CH2:9][CH2:10][CH2:11][C:12]2[C:20]3[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=3[NH:14][C:13]=2[CH:21]=O)[CH2:3]1.[CH3:23][NH:24][S:25]([C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][CH:36]=1)[NH:33][C:32](=[O:37])[CH2:31]2)(=[O:27])=[O:26]>>[CH3:23][NH:24][S:25]([C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][CH:36]=1)[NH:33][C:32](=[O:37])/[C:31]/2=[CH:21]\[C:13]1[NH:14][C:15]2[CH2:16][CH2:17][CH2:18][CH2:19][C:20]=2[C:12]=1[CH2:11][CH2:10][CH2:9][N:4]1[CH2:5][CH:6]([CH3:8])[NH:7][CH:2]([CH3:1])[CH2:3]1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 10176909N-methyl-2-oxoindoline-5-sulfonamideHCID 23498856HCID 23498856, compound

Product 1

HCID 23518503HCID 23518503, compoundYield 60.4%

Procedure

3-[3-(3,5-Dimethyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde (67 mg, 0.22 mmol) was condensed with 5-methylaminosulfonyloxindole (50 mg, 0.22 mmol) following the procedure used in Example 1 to provide (68 mg, 60% yield) of the desired compound.

Sources & evidence

ORD record
ord-b27200809f9f4b14ab5b879902287a1b
Source dataset
uspto-grants-2004_08
Patent number
US06777417B2

Reaction notes

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