HCID 23498854, compound → HCID 60104774, compound

HRID 1836158Notes

Reaction equation

HRID 1836158 reaction equation
[CH3:1][CH:2]1[NH:7][CH:6]([CH3:8])[CH2:5][N:4]([CH2:9][CH2:10][CH2:11][C:12]2[C:20]3[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=3[NH:14][C:13]=2[CH:21]=O)[CH2:3]1.[CH2:23]([S:25]([C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][CH:36]=1)[NH:33][C:32](=[O:37])[CH2:31]2)(=[O:27])=[O:26])[CH3:24]>>[CH3:8][CH:6]1[NH:7][CH:2]([CH3:1])[CH2:3][N:4]([CH2:9][CH2:10][CH2:11][C:12]2[C:20]3[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=3[NH:14][C:13]=2/[CH:21]=[C:31]2\[C:32](=[O:37])[NH:33][C:34]3[C:30]\2=[CH:29][C:28]([S:25]([CH2:23][CH3:24])(=[O:27])=[O:26])=[CH:36][CH:35]=3)[CH2:5]1

Participants

3

Reactant 2

HCID 23498854HCID 23498854, compoundHCID 23498856HCID 23498856, compound

Product 1

HCID 60104774HCID 60104774, compoundYield 53.4%

Procedure

3-[3-(3,5-Dimethyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde (62 mg, 0.22 mmol), prepared as described in Example 24, was condensed with 50 mg (0.22 mmol) of 5-ethylsulfonyloxindole to provide (60 mg, 53% yield) of the desired compound.

Sources & evidence

ORD record
ord-6b4a705d305b4df2af3285d415287510
Source dataset
uspto-grants-2004_08
Patent number
US06777417B2

Reaction notes

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