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Potassium Carbonate → methyl 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Chloro-4-methoxybenzylamine | HCID 738038 | — |
| 反応物 | methyl 3-[7-chloro-1-methyl-3-propyl-1H-pyrazolo[4,3-d)pyrimidin-5-yl]propionate | HCID 11150640 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | methyl 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate | HCID 11774810 | 105.3% |
反応手順
3 g of methyl 3-[7-chloro-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate and 1.9 g of 3-chloro-4-methoxybenzylamine (“A”) in 50 ml of dimethylformamide (DMF) are stirred at 60° for 12 hours in the presence of potassium carbonate. After filtration, the solvent is removed and the mixture is worked up in the customary manner. 4.6 g of methyl 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate are obtained as a colourless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06777419B1 |
| 出典データセット | uspto-grants-2004_08 |
| ORD ID | ord-7a6d2041face4b23bc606ecb3a72658d |
| 出典メモ | uspto-grants-2004_08 |