N-Acetyl-L-Cysteine → Bis-(2-Acetylamino-2-Carboxyethylthio)succinimidyl Hexane

Participants

Reaction Conditions

Reaction Steps

Bis-maleimidohexane (0.05 g, 1.81×10−4 mol) and N-acetylcysteine (0.059 g, 3.62×10−4 mol) were dissolved in pyridine (1 ml). The reaction was stirred at 40° C. for 24 h. The solvent was removed in vacuo and the residue was dissolved in ethanol (5 ml) and the solvent removed in vacuo. This procedure was repeated 3 times more. The residue of the title compound weighed 0.1 g.

Provenance & Evidence