HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(2-Chlorophenyl)cyclopropanecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,2-Dibromopropane | HCID 6553 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (o-Chlorophenyl)acetonitrile | HCID 76112 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-Chlorophenyl)cyclopropanecarbonitrile | HCID 10313355 | — |
Reaction Steps
A solution of 13.1 g of 2-chlorophenylacetonitrile and 20.3 g of 1,2-dibromopropane in 142 ml of DMF is mixed with 9 g of sodium hydride [55-65% in oil] at room temperature. It is stirred for several hours and carefully added to water. After extraction with ethyl acetate and filtration by silica gel, the desired product is obtained: 13.1 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06777409B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-397b8d46f3e245408d763401f2a640de |
| Source note | uspto-grants-2004_08 |