Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | CID 406 | HCID 406 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | HCID 21908405 | HCID 21908405 | — |
| Product | HCID 69517079 | HCID 69517079 | — |
Reaction Steps
14.3 g of phosphonate in 40 ml of tetrahydrofuran is mixed at 0° C. with 29 ml of lithium diisopropylamide. It is stirred for 20 more minutes at 0° C. 9.7 g of 1-(2-chlorophenyl)-1-cyclopropane carbaldehyde in 40 ml of tetrahydrofuran is added in drops. After 24 hours at room temperature, it is mixed with water, extracted with ethyl acetate, ethyl acetate solution is washed with water and dried (Na2SO4). After concentration by evaporation, 15.5 g of the product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06777409B2 |
|---|
| Source dataset | uspto-grants-2004_08 |
|---|
| ORD ID | ord-80363d1adbbd4f62b1c25dac4b2a4ceb |
|---|
| Source note | uspto-grants-2004_08 |
|---|
