HCID 69517079, compound → HCID 69516577, compound

HRID 1836188Notes

Reaction equation

HRID 1836188 reaction equation
C([O:3][C:4](=[O:20])[C:5]([O:17][CH2:18][CH3:19])=[CH:6][C:7]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])[CH2:9][CH2:8]1)C>[OH-].[Na+]>[CH2:18]([O:17][C:5](=[CH:6][C:7]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])[CH2:8][CH2:9]1)[C:4]([OH:20])=[O:3])[CH3:19]

Participants

3

Reactant 1

HCID 69517079HCID 69517079, compound

Product 1

HCID 69516577HCID 69516577, compoundYield 80.4%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

15.4 g of 2-ethoxy-3-[1-(2-chlorophenyl)-1-cyclopropyl]-acrylic acid ethyl ester in 350 ml of 1 M sodium hydroxide solution (ethanol-water 2:1) is stirred for 24 hours at room temperature. Solvent is distilled off, residue is distributed between water and diethyl ether, water solution is acidified with 2N hydrochloric acid, and extracted with diethyl ether. After the organic phase is washed with water, dried (Na2SO4) and concentrated by evaporation, 11.2 g of the product is obtained.

Workup

  1. distillationSolvent is distilled off
  2. extractionextracted with diethyl ether
  3. washAfter the organic phase is washed with water
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-77587aff75e34ef9b1f79a6c6f36dde7
Source dataset
uspto-grants-2004_08
Patent number
US06777409B2

Reaction notes

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