Thionyl Chloride → 2,3,4,5-Tetrafluorobenzoyl chloride

Participants

Reaction Steps

To the solution of 2,3,4,5-tetrafluorobenzoic acid (compound f, 29.5 g, 150 mmol) in 200 ml THF, was added SOCl2 20 ml dropwise at 0° C., then the mixture was stirred at room temperature for 6 hours. After removal of the solvent and excessive SOCl2, the residue was used for the next step directly.

Provenance & Evidence