反应详情

温度

75 °C

To the compound from Step C (50 mg, 0.16 mmol) was added saturated ammonia in methanol (4 mL). The mixture was stirred at 75° C. for 72 h in a closed container, cooled and evaporated in vacuo. The crude mixture was purified on silica gel using methanol/dichloromethane (1:9) as eluent. Fractions containing the product were pooled and evaporated in vacuo to give the desired product (29 mg) as a colorless powder.

1. temperaturecooled
2. customevaporated in vacuo
3. customThe crude mixture was purified on silica gel
4. additionFractions containing the product
5. customevaporated in vacuo