HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1836254Generated: November 1, 2026
Ammonia → 4-Amino-7-[3,5-bis-o-(2,4dichlorophenylmethyl)-2-c-vinyl-beta-d-ribofuranosyl]-7h-pyrrolo[2,3-d]pyrimidine
https://huagongshe.com/reaction/1836254
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Chloro-7-[3,5-bis-o-(2,4-dichlorophenylmethyl)-2-c-vinyl-beta-d-ribofuranosyl]-7h-pyrrolo[2,3-d]pyrimidine | HCID 87285362 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Amino-7-[3,5-bis-o-(2,4dichlorophenylmethyl)-2-c-vinyl-beta-d-ribofuranosyl]-7h-pyrrolo[2,3-d]pyrimidine | HCID 67142614 | — |
Reaction Steps
The compound from Step B (80, mg) was dissolved in the minimum amount of 1,4-dioxane and placed in a stainless steel bomb. The bomb was cooled to −78° C. and liquid ammonia was added. The bomb was sealed and heated at 90° C. for 24 h. The ammonia was allowed to evaporate and the residue concentrated to a white solid which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06777395B2 |
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| Source dataset | uspto-grants-2004_08 |
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| ORD ID | ord-70c729989242404484b30952fa3e7a4e |
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| Source note | uspto-grants-2004_08 |
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