反应详情

To the compound from Step A (735 mg, 1.16 mmol) was added methanolic ammonia (saturated at 0° C.) (20 mL). The mixture was heated in a stainless steel autoclave at 80° C. overnight, then cooled and the content evaporated in vacuo. The crude mixture was purified on silica gel using ethyl acetate/hexane as the eluent. Fractions containing the product were pooled and evaporated in vacuo to give the desired product (504 mg) as colorless foam.

1. temperaturecooled
2. customthe content evaporated in vacuo
3. customThe crude mixture was purified on silica gel
4. additionFractions containing the product
5. customevaporated in vacuo