Bromine → HCID 23499174, compound

Participants

Reaction Steps

To a solution of 2-(5-Indanylamino)-2-imidazoline (100 mg, 0.497 mmol) in acetic acid (7 mL) was added a solution of bromine (153 mg, 0.957 mmol) in acetic acid (1 mL). The resulting mixture was stirred for 5 min, and the solvent was removed. The residue was flash chromatographed over silica gel (EtOAc:MeOH:Et3N=6:2:1) to afford a solid, which was recrystallized from dichloromethane/hexane to give a beige solid (25 mg, 14% yield): mp 220-221° C.; HRMS (EI) calcd. for C12H14N3Br 279.0371, obsd. 279.0383. Anal. Calcd. for C12H14N3BrH·Br2/3H2O: C, 38.63; H, 4.41; N, 11.26; Br, 42.83. Found: C, 39.10; H, 4.21; N, 10.87; Br, 42.37.

Provenance & Evidence