Hydrochloric Acid → HCID 178494612, compound

Participants

Reaction Steps

To 2-(tert-Butyldimethylsilyl)-4-(methoxyquinolin-4-yl-methyl)-imidazole-1-sulfonic acid dimethylamide. (0.32 g, 0.672 mmol), 7 ml of 1.5N HCl was added and the solution refluxed for two hours. The reaction mixture was concentrated, partitioned between water(10 ml) and EtOAc (2×10 ml). The organic layer was dried over sodium sulfate, filtered, concentrated and column purified (CH2Cl2: MeOH: methanol-NH-2 (1.0 M); (4.5:0.25:0.25) to yield 0.160 g (100%) of the product as a syrup.

Provenance & Evidence