Trifluoroacetic acid → HCID 10280152, compound

Participants

Reaction Steps

4-Nitroaniline (200 mg), 0.15 ml of ethyl vinyl ether, and 0.1 ml of trifluoroacetic acid were dissolved in 5 ml of acetonitrile, and 500 mg of 3-(tert-butyldiphenylsilanoxy)-2,2-dimethylpropionaldehyde was added at 0° C. After 6 hours of stirring at room temperature, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent; hexane:ethyl acetate=10:1-8:1) to obtain 34 mg of the title compound. Its physical properties are shown below.

Provenance & Evidence