Ammonium Hydroxide → HCID 60104785, compound

Participants

Reaction Conditions

Reaction Steps

(R)-2-Methyl-N-(2-phenyl-propyl)-benzamide (2.1 g; 8.29 mmol) is added all at once to polyphosphoric acid (pre-heated to 140°) and the resulting mixture is stirred at 140° C. for 1 hour. The mixture is poured onto ice, made basic with concentrated NH4OH, and diluted with dichloromethane (100 mL). The phases are separated, and the aqueous phase extracted with dichloromethane (3×70 mL). The combined organics are washed with water (1×50 mL) and brine (1×50 mL), dried over magnesium sulfate, and evaporated in vacuo. The residue is purified by flash chromatography over silica gel (eluting with ether) to give the product as a yellow oil.

Provenance & Evidence