Methanol → HCID 23499504, compound

Participants

Reaction Steps

To a solution of 3-(2-benzylsulfonylhydrazino)-1-[(2-ethoxycarbonyl)ethyl]-6-methylpyrazinone, the product of Example 30 (0.398 g, 1.01 mmol), in tetrahydrofuran (10 mL) containing 5% methanol, is added sodium borohydride (0.229 g, 6.07 mmol) at room temperature. The reaction mixture is stirred for 5 hours. Water (2 mL) is then added and the mixture is fractionated between dichloromethane and water. The organic phase is dried over anhydrous sodium sulfate and is concentrated under reduced pressure. The crude residue is purified using silica gel column chromatography with ethyl acetate/n-hexane as eluent to afford the title compound.

Provenance & Evidence