HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 1-Methylpiperidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Methylpiperidine-4-carboxylic acid | HCID 2736939 | — |
Reaction Steps
Isonipecotic acid (50 g, 0.387 mole) was dissolved in water (500 ml) and 37% formaldehyde (125 ml). 10% Palladium on carbon (50 g) was added and the mixture was shaken under a hydrogen atmosphere at 60 psi at room temperature for 18 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06777428B1 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-d2c514050ea6435589e2e2e8418f223b |
| Source note | uspto-grants-2004_08 |