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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1836388Generated: October 25, 2026

2,5-Difluorobenzoyl chloride → 4-[3-(2,5-Difluorobenzamidyl)benzoyl]-1-methylpiperidine

https://huagongshe.com/reaction/1836388

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,5-Difluorobenzoyl chlorideHCID 588082—
Reactant4-[3-Aminobenzoyl]-1-methylpiperidineHCID 10130651—
Product4-[3-(2,5-Difluorobenzamidyl)benzoyl]-1-methylpiperidineHCID 69355052108.5%

Reaction Steps

Beginning with 4-[3-aminobenzoyl]-1-methylpiperidine (25 mg, 0.115 mmol) and 2,5-difluorobenzoyl chloride (28 μL, 0.229 mmol), 44.7 mg (>100%) of the title compound were recovered.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06777428B1
Source datasetuspto-grants-2004_08
ORD IDord-cc6751c062d648fcbe0c013bb450070a
Source noteuspto-grants-2004_08