Hydrochloric Acid → HCID 69353998, compound

Participants

Reaction Steps

To a suspension of 2.8 g (8.48 mol) of 4-(3-nitrobenzoyl)-1-trifluoromethylcarbonylpiperidine, 4-(2-nitrobenzoyl)-1-trifluoromethylcarbonylpiperidine, and 4-(4-nitrobenzoyl)-1-trifluoromethylcarbonylpiperidine mixture (62:33:5) in isopropanol (60 mL) was added HCl 37% (10 mL). The reaction mixture was refluxed for 8 h and rapidly a complete dissolution was observed. Then, the solution was allowed to cool to room temperature and post-agitated for 4 h. The precipitate was filtered, rinsed with isopropanol (2×5 mL) and ethyl ether (5 mL). Drying under vacuum at 50° C. afforded pure 4-(3-nitrobenzoyl)piperidine HCl (956 mg, 42%).

Provenance & Evidence