HCID 69353998, compound → HCID 69356056, compound

Participants

Reaction Steps

A Parr bottle of 220 mL thermostated at 28-29° C. was charged with a suspension of Pd/C 10% (18.2 mg) in methanol (20 mL) followed by 4-(3-nitrobenzoyl)piperidine HCl (1 g 3.69 mmol). The reactor was placed under hydrogen atmosphere(40 PSI). The hydrogenation was complete within 1 hour. The catalyst was removed by filtration and rinsed with methanol (2×5 mL). The filtrate was rota-evaporated and the solid dried under vacuum at 50° C. for 8 hours to give 890 mg (100%) of crude 4-(3-aminobenzoyl)piperidine HCl.

Provenance & Evidence