反应详情

To a mixture of 2-nitroaniline (1 g, 7.23 mmol) in acetic acid (5 mL) was added phthalic anhydride (1.29 g, 8.7 mmol) followed by stirring at ambient temperature for 16 h. The mixture was then heated at reflux for 20 h. Upon cooling, a yellow precipitate formed and was collected by filtration. The filtrate was washed with acetic acid and was dried under a under a stream of air to give 2.35 g (100%) of 2-(2-nitrophenyl)isoindole-1,3-dione: 1H NMR (300 MHz, DMSO-d6) δ8 8.21 (m, 1H), 8.02-7.95 (m, 5H), 7.77 (m, 2H).

1. temperatureThe mixture was then heated
2. temperatureat reflux for 20 h
3. temperatureUpon cooling
4. customa yellow precipitate formed
5. filtrationwas collected by filtration
6. washThe filtrate was washed with acetic acid
7. customwas dried under a under a stream of air