HCID 23519150, compound → HCID 74058493, compound

Participants

Reaction Steps

Reaction of (2,2-dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-acetyl chloride with [N-(3,4-dichlorobenzyl)aminooxy]-acetic acid tert-butyl ester as described in the preparation of compound 1-A gave the title amide as white crystals (49% yield): mp 127-129° C. (ethyl acetate-hexane). 1HNMR 400 MHz (CDCl3) δ (ppm): 1.51 (9H, s, t-Bu), 1.78 (6H, s, CH3), 4.38 (2H, s, CH2), 4.90 (2H, s, CH2), 6.49 (1H, s, CH), 7.28 (1H, dd, J=2.5 Hz and J=8.0 Hz, aromatic), 7.41 (1H, d, J=8.0 Hz, aromatic), 7.53 (1H, d, J=2.5 Hz, aromatic). Anal. calcd for C20H23Cl2NO7: C, 52.19; H, 5.04; N, 3.04. Found: C, 52.25; H, 5.11; N, 2.93.

Provenance & Evidence