HCID 23499563, compound → HCID 74057333, compound

Participants

Reaction Steps

Reaction of (2,2-dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-acetyl chloride with O-(2-dimethylamino-ethyl)-N-(4-fluorobenzyl)-hydroxylamine as described in the preparation of compound 1-A gave the title amide as white crystals (30% yield): mp 95-96° C. (ether-hexane). 1HNMR 400 MHz (DMSO-d6) δ (ppm): 1.70 (6H, s, CH3), 2.16 (6H, s, NCH3), 2.44 (2H, t, J=5.3 Hz, CH2), 3.97 (2H, t, J=5.3 Hz, CH2), 4.79 (2H, s, NCH2), 6.52 (1H, s, CH), 7.18 (2H, m, aromatics), 7.34 (2H, m, aromatics). Anal. calcd for C18H23FN2O5: C, 59.00; H, 6.32; N, 7.64. Found: C, 58.73; H, 6.13; N, 7.40.

Provenance & Evidence