{4-(Benzyloxy)-3-[(4-fluorophenyl)sulphonyl]phenyl}methanol → 4-(Benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzaldehyde

Participants

Reaction Steps

2.1 g (5.64 mmol) of {4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]phenyl}methanol (Example V) are dissolved in 25 ml of dichloromethane. At room temperature, 4.9 g (56.39 mmol) of manganese(IV) oxide are added. The mixture is stirred at room temperature overnight. The reaction mixture is then filtered through Celite and the solvent is removed under reduced pressure. This gives 1.82 g (86% of theory) of 4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzaldehyde.

Provenance & Evidence