Propanoic acid, 2-bromo-2-methyl-, ethyl ester → Ethyl 2-(4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenoxy)-2-methylpropanoate

HRID 1836557Notes

Reaction equation

HRID 1836557 reaction equation
[CH2:1]([O:8][C:9]1[CH:24]=[CH:23][C:12]([CH2:13][C:14]2[C:19]([CH3:20])=[CH:18][C:17]([OH:21])=[CH:16][C:15]=2[CH3:22])=[CH:11][C:10]=1[S:25]([C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)(=[O:27])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:35][C:36]([CH3:43])(Br)[C:37]([O:39][CH2:40][CH3:41])=[O:38]>>[CH2:1]([O:8][C:9]1[CH:24]=[CH:23][C:12]([CH2:13][C:14]2[C:19]([CH3:20])=[CH:18][C:17]([O:21][C:36]([CH3:43])([CH3:35])[C:37]([O:39][CH2:40][CH3:41])=[O:38])=[CH:16][C:15]=2[CH3:22])=[CH:11][C:10]=1[S:25]([C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)(=[O:26])=[O:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 234996174-{4-(Benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenol

Product 1

HCID 23499594Ethyl 2-(4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenoxy)-2-methylpropanoate

Procedure

This compound was obtained analogously to Example XI starting from 4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenol (Example X) and ethyl dimethylbromoacetate.

Workup

  1. customThis compound was obtained analogously to Example XI

Sources & evidence

ORD record
ord-3b4ff2bc0d0445f4bb2f1eefd190d05d
Source dataset
uspto-grants-2004_08
Patent number
US06777442B2

Reaction notes

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