Ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate → (4-{3-[(4-Fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid

Participants

Reaction Steps

37 mg (0.08 mmol) of ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate (Example 1) are dissolved in 1 ml of ethanol, and a few drops of 1 N aqueous sodium hydroxide solution are added. The mixture is stirred at room temperature for thirty minutes and the solvent is then removed under reduced pressure. Water is added to the residue, and the mixture is extracted three times with ethyl acetate. The combined organic phases are dried with sodium sulphate and concentrated. This gives 32 mg (90% of theory) of (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid.

Provenance & Evidence