HCID 23518422, compound → HCID 69917388, compound

HRID 1836566Notes

Reaction equation

HRID 1836566 reaction equation
[CH:1]1[CH:10]=[CH:9][C:8]2[CH2:11][CH2:12][CH2:13][N:6]3[C:7]=2[C:2]=1[C@H:3]1[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][C@H:4]1[CH2:5]3.[ClH:24].Cl.[CH:26]1[CH:35]=[CH:34][C:33]2CCCN3[C:32]=2[C:27]=1[C@H]1CNC[C@H]1C3>>[ClH:24].[ClH:24].[C:26]1([C:10]2[CH:1]=[C:2]3[C:7]4=[C:8]([CH2:11][CH2:12][CH2:13][N:6]4[CH2:5][C@@H:4]4[CH2:14][NH:15][CH2:16][C@H:3]34)[CH:9]=2)[CH:35]=[CH:34][CH:33]=[CH:32][CH:27]=1

Participants

3

Reactant 2

HCID 23518422HCID 23518422, compoundHCID 131724533HCID 131724533, compound

Product 1

HCID 69917388HCID 69917388, compound

Procedure

Following the procedure described in EXAMPLE 7, Part A, (±)-cis-tert-butyl 5,6,8a,9,11,11a-hexahydro-4H-pyrido[3,2,1-ij]pyrrolo[3,4-c]quinoline-10(8H)-carboxylate, an intermediate from EXAMPLE 11, was converted into the title compound as an oil. 1H NMR (CDCl3): δ 6.90 (s, 2H), 3.90-3.77 (m, 1H), 3.61-3.52 (m, 1H), 3.35-3.25 (m, 2H), 3.20-3.12 (m, 2H), 3.08-2.95 (m, 2H), 2.85-2.68 (m, 3H), 2.57-2.47 (m, 1H), 1.98-1.88 (m, 2H), 1.42 (s, 9H).

Sources & evidence

ORD record
ord-f1144afd27f544508c5bf07486f1868f
Source dataset
uspto-grants-2004_08
Patent number
US06777406B2

Reaction notes

Loading…