Bromobenzene → HCID 68523991, compound

Participants

Reaction Steps

A solution of (±)-cis-tert-butyl 2-amino-5,6,8a,9,11,11a-hexahydro-4H-pyrido[3,2,1-ij]pyrrolo[3,4-c]quinoline-10(8H)-carboxylate (0.08 g, 0.25 mmol), bromobenzene (0.04 g, 0.27 mmol), BINAP (0.001 g, 0.0015 mmol), sodium-t-butoxide, (0.06 g, 0.65 mmol) and Pd2DBA3 (0.0005 g, 0.0005 mmol) in 10 ml of degassed toluene was heated for 16 h at 90° C. The solution was cooled and filtered through a pad of silica gel and eluted with EtOAc. The volatiles were removed under reduced pressure to afford the title compound which was used without purification. LRMS (ES)+: 406.4 (M+H)+.

Provenance & Evidence