(Bromomethyl)cyclobutane → HCID 131724540, compound

Participants

Reaction Steps

Using bromomethylcyclobutane and following the procedures described in EXAMPLE 104, (±)-cis-5,6,8,8a,9,10,11,11a-octahydro-4H-pyrido[3,2,1-ij]pyrrolo[3,4-c]quinoline free base from EXAMPLE 11 was converted into the title compound of EXAMPLE 105 as an off-white powder. 1H NMR (dmso-D6) δ: 11.10 (broad s, 1H), 6.90-6.78 (m, 2H), 6.65-6.55 (m, 1H), 3.90-3.80 (m, 1H), 3.79-3.70 (m, 1H), 3.60-3.30 (m, 3H), 3.20-2.95 (m, 4H), 2.90-2.65 (m, 5H), 2.08-1.98 (m, 2H), 1.95-1.70 (m, 7H). LRMS (ES)+: 283.2 (M+H)+.

Provenance & Evidence