2-Butene, 1-bromo-3-methyl- → HCID 131724541, compound

Participants

Reaction Steps

Using 4-bromo-2-methyl-2-butene and following the procedures described in EXAMPLE 104, (±)-cis-5,6,8,8a,9,10,11,11a-octahydro-4H-pyrido[3,2,1-ij]pyrrolo[3,4-c]quinoline free base from EXAMPLE 11 was converted into the title compound of EXAMPLE 106 as an off-white powder. 1H NMR (dmso-D6) δ: 11.05 (broad s, 1H), 6.86 (t, 1H, J=6.2 Hz), 6.81 (t, 1H, J=7.0 Hz), 6.59 (q, 1H, J=7.3 Hz), 5.33-5.27 (m, 1H), 3.90-3.60 (m, 4H), 3.50-3.25 (m, 2H), 3.10-2.95 (m, 3H), 2.90-2.75 (m, 3H), 2.72-2.65 (m, 2H), 1.95-1.85 (m, 2H), 1.72 (s, 3H), 1.64 (s, 3H). LRMS (ES)+: 283.2 (M+H)+.

Provenance & Evidence