(2,4-Dichlorophenyl)boronic acid → HCID 60088309, compound

Participants

Reaction Steps

Using 2,4-dichlorophenylboronic acid and following the procedures described in EXAMPLE 20, (±)-cis tert-butyl 2-bromo-5,6,8,8a,9,10,12,12a-octahydro-4H,11H-quino[1,8-bc]-2,6-naphthyridine-11-carboxylate from EXAMPLE 127, Part F was converted into the title compound of EXAMPLE 128. 1H NMR (CDCl3) δ: 7.44 (d, 1H, J=1.6 Hz), 7.27-7.18 (m, 2H), 6.94 (B, 1H), 6.81 (s, 1H), 3.96 (dd, 1H, J=11.5, 3.1 Hz), 3.51-3.43 (m, 1H), 3.30-3.20 (m, 2H), 3.13 (d, 2H, J=7.3 Hz), 2.98-2.85 (m, 2H), 2.84-2.73 (m, 2H), 2.08-1.88 (m, 4H), 1.71-1.60 (m, 1H), 0.90-0.80 (m, 1H). LRMS (ES)+: 373.3 (M+H)+.

Provenance & Evidence