HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 1-amino-1-cyclopentanecarboxylate, HCl → 1-[(R)-2-bromo-3-methylbutanoylamino]cyclopentanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 1-amino-1-cyclopentanecarboxylate, HCl | HCID 11513856 | — |
| Reactant | (r)-2-Bromoisovaleric acid diisopropylamine salt | HCID 56845281 | — |
| Product | 1-[(R)-2-bromo-3-methylbutanoylamino]cyclopentanecarboxylic acid | HCID 59902414 | — |
Reaction Steps
The 1-[(R)-2-bromo-3-methylbutanoylamino]cyclopentanecarboxylic acid starting material is prepared essentially by methodology described in WO 99/55726 by condensation of (R)-2-bromo-3-methylbutanoic acid diisopropylamine salt (prepared from L-valine) with cycloleucine methyl ester hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06777443B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-2249e067b10c4a55af098f8f0f53c460 |
| Source note | uspto-grants-2004_08 |